Description
VaxxinOUT formula – Fucoidan – is a polysaccharide our high purity fucoidan derived from Laminaria japonica brown seaweed. Bioactivities associated with fucoidan include anti-oxidant, anti-tumor, anti-coagulant, anti-thrombotic, immunoregulatory, anti-viral and anti-inflammatory effects.
Anti-coagulant properties of fucoidan meaning fucoidan prevents blood clots from forming, which can help to prevent strokes, heart attacks, and other life-threatening conditions.
Fucoidan has been found to have anti-coagulant effects by inhibiting the activity of blood coagulation factors, such as thrombin and factor Xa. This makes fucoidan a potential alternative to traditional anticoagulant drugs, such as warfarin, which can have serious side effects and require close monitoring.
In addition to its anti-coagulant properties, fucoidan has also been shown to have anti-inflammatory and antioxidant effects, which can further contribute to its potential therapeutic benefits.
Fucoidan shown antimutagenic activities against aflatoxin and MNNG and cancer cell growth inhibition.
References:
Luthuli, S.; Wu, S.; Cheng, Y.; Zheng, X.; Wu, M.; Tong, H. Therapeutic Effects of Fucoidan: A Review on Recent Studies. Mar. Drugs 2019, 17, 487. https://doi.org/10.3390/md17090487
Cho, Eun-Ju Rhee, Sook-Hee Park, Kun-Young Antimutagenic and Cancer Cell Growth Inhibitory Effects of Seaweeds Published : 1997.12.01 https://koreascience.kr/article/JAKO199711920125131.page
Hui Zhang, Yibo Tang, Ying Zhang, Shuofeng Zhang, Jing Qu, Xu Wang, Ran Kong, Chunchao Han and Zhenquan Liu
Fucoxanthin: A Promising Medicinal and Nutritional Ingredient Volume 2015 | Article ID 723515 | https://doi.org/10.1155/2015/723515
VaxxinOUT formula – Fucoxanthin
Suppresses cancer cell growth
Anti-inflammatory
Cardiovascular and cerebrovascular -protective effects
Martin, L.J. Fucoxanthin and Its Metabolite Fucoxanthinol in Cancer Prevention and Treatment. Mar. Drugs 2015, 13, 4784-4798.
https://doi.org/10.3390/md13084784
Minkyung Bae, Mi-Bo Kim, Young-Ki Park, Ji-Young Lee, Health benefits of fucoxanthin in the prevention of chronic diseases, Biochimica et Biophysica Acta (BBA) – Molecular and Cell Biology of Lipids, Volume 1865, Issue 11, 2020, 158618, ISSN 1388-1981, https://doi.org/10.1016/j.bbalip.2020.158618
Hui Zhang, Yibo Tang, Ying Zhang, Shuofeng Zhang, Jing Qu, Xu Wang, Ran Kong, Chunchao Han, Zhenquan Liu, “Fucoxanthin: A Promising Medicinal and Nutritional Ingredient”, Evidence-Based Complementary and Alternative Medicine, vol. 2015, Article ID 723515, 10 pages, 2015. https://doi.org/10.1155/2015/723515
VaxxinOUT formula – Dihydroquercetine (DHQ) or Taxifolin (from Larix sibirica) is a flavonoid that is found in various plants, including the leaves and bark of the Dahurian larch tree.
Studies have shown that taxifolin has several health-promoting effects, including:
Antioxidant: Taxifolin has been shown to have strong antioxidant properties, which can help to prevent oxidative damage to cells and tissues and reduce the risk of certain diseases.
Anti-inflammatory: Taxifolin has been found to have anti-inflammatory effects, which can help to treat various conditions, such as rheumatoid arthritis and cardiovascular disease. The study found that treatment with taxifolin resulted in a significant reduction in markers of inflammation, such as tumor necrosis factor-α and interleukin-1β. These results suggest that taxifolin may have potential as a treatment for rheumatoid arthritis and other diseases associated with inflammation.
Cardioprotective: Taxifolin has been found to have cardioprotective effects, potentially helping to prevent heart disease by improving blood flow and reducing oxidative stress. taxifolin was effective in improving blood flow and reducing oxidative stress in rats with ischemia-reperfusion injury. The study found that treatment with taxifolin resulted in a significant improvement in blood flow and a reduction in oxidative stress markers, such as malondialdehyde and superoxide dismutase activity. These results suggest that taxifolin may have potential as a treatment for cardiovascular disease and other diseases associated with oxidative stress and blood flow issues.
Neuroprotective: Taxifolin has been shown to have neuroprotective properties, potentially helping to protect the brain from damage and improving cognitive function. Neurodegenerative diseases, such as Alzheimer’s disease and Parkinson’s disease, are a major public health concern. Neuroprotective drugs are commonly used to treat these diseases, but they can have serious side effects. Taxifolin has been shown to have neuroprotective properties, making it a potential alternative to traditional neuroprotective drugs. Taxifolin was effective in reducing oxidative stress and improving cognitive function in rats with scopolamine-induced memory impairment. The study found that treatment with taxifolin resulted in a significant reduction in oxidative stress markers, such as malondialdehyde, and an improvement in cognitive function, as measured by the Morris water maze test. These results suggest that taxifolin may have potential as a treatment for neurodegenerative
Anti-cancer: Taxifolin has been found to have anti-cancer properties
Christudas Sunil, Baojun Xu, An insight into the health-promoting effects of taxifolin (dihydroquercetin), Phytochemistry, Volume 166, 2019, 112066, ISSN 0031-9422, https://doi.org/10.1016/j.phytochem.2019.112066.
VaxxinOUT formula – Zeolite Clinoptilolite –
the detoxifying effects of zeolite clinoptilolite (ZC) and modified ZC in various animal and clinical studies. The ZC has been observed to reduce the accumulation of lead in the intestine of lead poisoned mice, restore cholinesterase activity in rats intoxicated with organophosphates, and improve physical fitness and efficiency of farm animals by removing harmful substances from the body. It also has a positive effect on farmed poultry, balancing the total intestinal microbial flora, reducing toxic effects of aflatoxins and increasing antioxidant activity. A clinical study also found that supplementation with PMA-ZC improved the integrity of the intestinal barrier in endurance-trained subjects and reduced the concentrations of zonulin, a marker of increased intestinal permeability.
the detoxifying effects of zeolite clinoptilolite (ZC) and modified ZC. Animal and clinical studies have shown that ZC has the ability to reduce the accumulation of lead in the intestine of lead poisoned mice, restore cholinesterase activity in rats intoxicated with organophosphates, improve physical fitness and efficiency of farm animals by removing harmful substances from the body, and have a positive effect on farmed poultry by balancing the total intestinal microbial flora and reducing toxic effects of aflatoxins. A clinical study found that PMA-ZC improved the integrity of the intestinal barrier in endurance-trained subjects and reduced the concentrations of zonulin, a marker of increased intestinal permeability.
Gut – Brain axis – Microbiome
Zeolite Clinoptilolite (ZC) may have a potential impact on the brain through the gut-brain axis. The exact mechanism of ZC on the brain is still unknown, but some studies suggest that it can reduce stress and improve sleep, as well as positively affect the brain through its gut-protective properties. Some studies have also shown the potential of ZC in protecting against oxidative stress and plaque burden in Alzheimer’s disease, but more extensive research is needed to establish its role as a treatment.
Zeolite (ZC) is a natural mineral with physical-chemical properties that make it suitable for absorbing and exchanging ions, improving its therapeutic potential. This exceptional ion-exchange capacity and surface area can be improved through micronization processes, in particular tribomechanical micronization (TMAZ) and PMA-ZC. ZC is used for environmental decontamination, oral supplementation for humans, and purifying water for livestock. PMA-ZC can also improve the gut microbiome and have a detoxifying, anti-inflammatory and antioxidant effect in the intestine, potentially improving overall health and wellbeing. Despite some promising results, more research is needed to understand the molecular mechanisms and potential risks of ZC. Preclinical research aims to find a food supplement that can be combined with traditional pharmacological treatment, with evidence suggesting a detoxifying role in removing toxic metabolites produced by drugs.
Mastinu, A.; Kumar, A.; Maccarinelli, G.; Bonini, S.A.; Premoli, M.; Aria, F.; Gianoncelli, A.; Memo, M. Zeolite Clinoptilolite: Therapeutic Virtues of an Ancient Mineral. Molecules 2019, 24, 1517. https://doi.org/10.3390/molecules24081517
Kraljević Pavelić Sandra, Simović Medica Jasmina, Gumbarević Darko, Filošević Ana, Pržulj Nataša, Pavelić Krešimir “Critical Review on Zeolite Clinoptilolite Safety and Medical Applications in vivo”, Frontiers in Pharmacology, vol. 9, 2018, ISSN 1663-9812 https://doi.org/10.3389/fphar.2018.01350
VaxxinOUT formula – Serrapeptase
Serratiapeptidase proteolytic enzymes have a strong target binding and specificity, making them useful in the treatment of infections, inflammation, and fibrotic disorders. Serrapeptase fibrinolytic activity is coupled with multiple properties, including proteolytic, caseinolytic, antifibrotic, anti-inflammatory, antiatherosclerotic, and antioxidant activity, suggests its potential benefits in reducing the severity of vascular complications involving thrombosis or coagulopathy. Serrapeptase shown ability to suppress growth factors, particularly TGF-β along with inhibiting oxidative stress and expression of pro-inflammatory cytokines, chemokines, adhesion molecules potential treatment for lung fibrosis (followed by severe inflammatory conditions)
Sharma Charu, Jha Niraj Kumar, Meeran M. F. Nagoor, Patil Chandragouda R., Goyal Sameer N., Ojha Shreesh, “Serratiopeptidase, A Serine Protease Anti-Inflammatory, Fibrinolytic, and Mucolytic Drug, Can Be a Useful Adjuvant for Management in COVID-19”, Frontiers in Pharmacology, vol.12; 2021; ISSN 1663-9812, https://doi.org/10.3389/fphar.2021.603997
Dinesh Kumar, Diksha Verma, Vikrant Abbot, A review on pharmaceutical, pharmacological and chemical aspects of serratiopeptidase as anti-inflammatory agent,
Materials Today: Proceedings, 2023, ISSN 2214-7853, https://doi.org/10.1016/j.matpr.2023.01.256.
Ethiraj, S., Gopinath, S. Production, purification, characterization, immobilization, and application of Serrapeptase: a review. Front. Biol. 12, 333–348 (2017). https://doi.org/10.1007/s11515-017-1461-3
VaxxinOUT formula – Heavy metal chelation – Humuc acid, fulvic acid, mineral combination from natural sources
Humic acid, a natural organic substance found in soil and water, is known for its chelating properties. Chelating agents are substances that can bind with metal ions and form complex molecules, and they have been widely studied for their potential benefits for human health. Polyanionic compounds like humic acid shown anti-thrombotic properties. Humic acid was suppress the formation of fibrin monomers from fibrinogen through inhibition of thrombin, a coagulation enzyme.
Vašková, J., Vaško, L., Mudroň, P. et al. Effect of humic acids on lead poisoning in bones and on a subcellular level in mitochondria. Environ Sci Pollut Res 27, 40679–40689 (2020). https://doi.org/10.1007/s11356-020-10075-w
Klocking HP, Hoffmann A, Fareed J. Influence of hyper sulfatedlactobionic acid amides on tissue plasminogen activator release. In: Seminars in thrombosis and hemostasis, Thieme Medical Publishers, Inc; 1991;17:379-84. https://doi.org/10.1055/s-2007-1002639
Socol David C., Clinical review of humic acid as an antiviral: Leadup to translational applications in clinical humeomics, Frontiers in Pharmacology, 13, 2023
1663-9812, https://doi.org/10.3389/fphar.2022.1018904
Klocking, R. “Humic substances as potential therapeutics.” Humic Substances in the Global Environment and Implications on Human Health. Elsevier, Amsterdam (1994): 1245-1257.
VaxxinOUT V2 Formula
Advanced Herbal Support for Post-COV*D and Post-Va***ne Recovery
VaxxinOUT V2 is an advanced herbal supplement, scientifically crafted to alleviate symptoms associated with Post-acute Sequelae of SARS-CoV-2 infection (PASC) and vaccine-related adverse effects. Based on Professor Desire’s advanced technologies and the clinical principles outlined in the McCullough Protocol, VaxxinOUT V2 uses potent, natural ingredients to support your body’s healing from chronic inflammation, oxidative stress, and immune dysregulation caused by viral infection or vaccination.
Key Ingredients:
Bromelain in VaxxinOUT V2: Bromelain, an enzyme found in pineapples, is known for its anti-inflammatory and detoxifying properties, making it beneficial for post-vaccine recovery:
- Reduces Inflammation: Bromelain helps lower inflammation caused by the immune response to vaccines, relieving symptoms such as swelling, pain, and discomfort.
- Breaks Down Proteins: It assists in breaking down spike proteins introduced by certain COVID-19 vaccines, potentially reducing lingering adverse effects.
- Improves Circulation: Bromelain enhances blood flow, which helps flush out toxins and vaccine-related byproducts more efficiently.
- Immune System Support: By modulating immune responses, bromelain helps balance the body’s reaction post-vaccination.
Bromelain: A potential therapeutic application in SARS-CoV-2 infected patients
DOI: 10.17352/aaa.000011
Role of Pineapple and its Bioactive Compound Bromelain in COVID 19
DOI: https://doi.org/10.2174/1573401319666230418104554
Bromelain Inhibits SARS-CoV-2 Infection in VeroE6 Cells
DOI: 10.1101/2020.09.16.297366
Bromelain inhibits SARS‐CoV‐2 infection via targeting ACE‐2, TMPRSS2, and spike protein
DOI: 10.1002/ctm2.281
The combination of bromelain and curcumin as an immune-boosting nutraceutical in the prevention of severe COVID-19
DOI:https://doi.org/10.1016/j.metop.2020.100066
Curcumin in VaXXinOUT V2: Curcumin, the active compound in turmeric, plays a significant role in supporting vaccine detoxification due to its powerful anti-inflammatory and antioxidant properties:In summary, curcumin assists in vaccine detox by reducing inflammation, neutralizing free radicals, supporting liver detox, and modulating the immune system, promoting overall recovery.
- Reduces Inflammation: Vaccination can trigger prolonged inflammation in some individuals. Curcumin helps calm this response, alleviating symptoms like muscle pain, swelling, and fatigue.
- Antioxidant Protection: Curcumin neutralizes harmful free radicals that may be generated during the body’s immune response to vaccines, preventing oxidative stress and cellular damage.
- Supports Liver Detox: The liver is crucial for removing toxins, including those related to vaccination. Curcumin enhances liver function, aiding the body’s detoxification process.
- Immune Modulation: Curcumin helps regulate immune activity, balancing overactive immune responses that may occur post-vaccine.
Curcumin – Boosting the immunity of COVID-19-vaccinated populations
DOI: 10.4103/japtr.japtr_54_22
Effectiveness of Curcumin on Outcomes of Hospitalized COVID-19 Patients: A Systematic Review of Clinical Trials
DOI: https://doi.org/10.3390/nu14020256
Curcumin Confers Anti-Inflammatory Effects in Adults Who Recovered from COVID-19 and Were Subsequently Vaccinated: A Randomized Controlled Trial
DOI: https://doi.org/10.3390/nu15071548
Antiviral and immunomodulatory activity of curcumin: A case for prophylactic therapy for COVID-19
DOI: 10.1016/j.heliyon.2021.e0635
Nattokinase in VaxxinOUT V2: Nattokinase, an enzyme from fermented soybeans (natto), aids vaccine detoxification in several ways:
- Anti-inflammatory: Nattokinase helps lower inflammation, alleviating post-vaccine symptoms like joint pain and fatigue.
- Breaks Down Clots: It dissolves fibrin, reducing abnormal blood clot formation, which may occur after COVID-19 vaccination.
- Spike Protein Breakdown: Early research suggests nattokinase may help degrade lingering spike proteins from mRNA vaccines.
- Improves Circulation: By enhancing blood flow, it supports the body’s natural detox process, helping flush out vaccine-related byproducts.
In short, nattokinase promotes better circulation, reduces inflammation, and supports detox, making it useful for post-vaccine recovery.
Degradative Effect of Nattokinase on Spike Protein of SARS-CoV-2
DOI: https://doi.org/10.3390/molecules27175405
Proteolytic Targets for SARS-CoV-2 Spike Protein Degradation: Hope for Systemic Detoxification
DOI: Spike detox
Natto extract, a Japanese fermented soybean food, directly inhibits viral infections including SARS-CoV-2 in vitro
DOI: https://doi.org/10.1016/j.bbrc.2021.07.034
Automated microscopic measurement of fibrinaloid microclots and their degradation by nattokinase, the main natto protease
DOI: https://doi.org/10.1101/2024.04.06.588397
NAC (N-Acetyl Cysteine) in VaxxinOUT V2: N-Acetyl Cysteine (NAC) is a powerful antioxidant that plays a key role in detoxifying the body, making it useful for post-vaccine recovery:
- Boosts Glutathione: NAC increases levels of glutathione, the body’s master antioxidant, which helps neutralize harmful toxins and oxidative stress triggered by the immune response to vaccines.
- Detoxifies Harmful Substances: NAC supports liver function, enhancing the body’s natural detox pathways to break down and eliminate vaccine-related byproducts.
- Reduces Inflammation: NAC reduces inflammation and protects cells from damage, potentially alleviating post-vaccine symptoms like fatigue and muscle aches.
- Protects Against Clots: NAC has anticoagulant properties that help prevent abnormal blood clotting, which has been associated with some vaccines.
Rationale for the use of N‐acetylcysteine in both prevention and adjuvant therapy of COVID‐19
DOI: 10.1096/fj.202001807
N-Acetylcysteine to Combat COVID-19: An Evidence Review
DOI: https://doi.org/10.2147/TCRM.S273700
BRIEF REVIEW OF N-ACETYLCYSTEINE AS ANTIVIRAL AGENT: POTENTIAL APPLICATION IN COVID-19
DOI: https://doi.org/10.32553/jbpr.v9i3.764
In summary, NAC aids in vaccine detoxification by boosting antioxidant defenses, supporting liver detox, reducing inflammation, and protecting against clotting.
Milk Thistle in VaxxinOUT V2: Milk thistle is a powerful herb known for its liver-protective and detoxifying properties, making it valuable for vaccine detoxification:
- Supports Liver Function: Milk thistle’s active compound, silymarin, enhances liver health, helping the body process and eliminate toxins, including vaccine-related byproducts.
- Antioxidant Properties: It provides strong antioxidant support, neutralizing free radicals and reducing oxidative stress that may occur after vaccination.
- Reduces Inflammation: Milk thistle has anti-inflammatory effects that help mitigate post-vaccine symptoms like muscle aches and fatigue by calming the immune response.
- Promotes Cell Repair: It supports regeneration of liver cells, aiding the body’s overall detoxification capacity.
The favorable impacts of silibinin polyphenols as adjunctive therapy in reducing the complications of COVID-19: A review of research evidence and underlying mechanisms
DOI: https://doi.org/10.1016/j.biopha.2022.113593
SARS-CoV-2: Silibinin Prospects in Antiviral Drug Development
DOI:10.36349/easjacc.2021.v03i04.005
Bioactive Compounds from Plants and their Immune Potential against Corona Virus
DOI: https://doi.org/10.2174/1573401318666220308155721
Antiviral Efficacy of Selected Natural Phytochemicals against SARS-CoV-2 Spike Glycoprotein Using Structure-Based Drug Designing
DOI: https://doi.org/10.3390/molecules27082401
In summary, milk thistle aids in vaccine detox by improving liver function, providing antioxidant protection, reducing inflammation, and promoting cellular repair.
Taraxacum Officinale (Dandelion) in VaxxinOUT V2 : Taraxacum officinale, commonly known as dandelion, is a potent herb with detoxifying properties that support post-vaccine recovery:
- Supports Liver and Kidney Detox: Dandelion acts as a natural diuretic, promoting liver and kidney function to help flush out toxins and vaccine-related byproducts from the body.
- Rich in Antioxidants: It provides powerful antioxidants that help neutralize free radicals, protecting cells from oxidative stress caused by the immune response to vaccines.
- Reduces Inflammation: Dandelion has anti-inflammatory effects that help ease symptoms like muscle pain, swelling, and fatigue, promoting faster recovery.
- Immune System Support: It helps balance immune responses, ensuring a proper recovery after vaccination without excessive immune activity.
In Vitro Effect of Taraxacum officinale Leaf Aqueous Extract on the Interaction between ACE2 Cell Surface Receptor and SARS-CoV-2 Spike Protein D614 and Four Mutants
DOI: https://doi.org/10.3390/ph14101055
Common dandelion (Taraxacum officinale) efficiently blocks the interaction between ACE2 cell surface receptor and SARS-CoV-2 spike protein D614, mutants D614G, N501Y, K417N and E484K in vitro
DOI: https://doi.org/10.1101/2021.03.19.435959
Elimination/Neutralization of COVID-19 Vaccine-Produced Spike Protein: Scoping Review
DOI: https://doi.org/ 10.30654/MJND.10034
Common dandelion (Taraxacum officinale) leaf extract efficiently inhibits SARS-CoV-2 Omicron infection in vitro
DOI: https://doi.org/10.1101/2022.12.22.521558
In summary, dandelion aids in vaccine detox by supporting liver and kidney detoxification, providing antioxidants, reducing inflammation, and balancing immune responses.
How It Works:
The scientific article “Clinical Approach to Post-acute Sequelae After COVID-19 Infection and Vaccination” by Nicolas Hulscher, Brian C. Procter, Cade Wynn, and Peter A. McCullough, emphasizes that post-viral and post-vaccine syndromes can manifest with prolonged inflammation, immune dysregulation, and oxidative stress. VaxxinOUT V2 targets these core issues by using ingredients that:
- Combat chronic inflammation and oxidative stress
- Support the body’s natural detoxification processes
- Enhance immune system function
- Promote tissue repair and reduce brain fog, fatigue, and other lingering symptoms.
Why Choose VaxxinOUT V2?
- Clinically-Inspired: VaxxinOUT V2 is designed with Professor Desire’s advanced technologies and the McCullough Protocol principles in mind, a scientifically-backed approach for treating PASC.
- Natural and Safe: Our formula uses only the highest-quality, all-natural ingredients with proven safety and efficacy.
- Comprehensive Support: VaxxinOUT V2 is designed to target multiple aspects of post-COVID and post-vaccine recovery, helping restore balance to the immune system and aiding the body in the healing process.
- Charged with Professor Desire’s advanced technologies, QBES, Zeta potentization
- https://www.researchgate.net/publication/375814234_Clinical_Approach_to_Post-acute_Sequelae_After_COVID-19_Infection_and_Vaccination/download?_tp=eyJjb250ZXh0Ijp7ImZpcnN0UGFnZSI6Il9kaXJlY3QiLCJwYWdlIjoiX2RpcmVjdCJ9fQ
