What is Autophagy?
Autophagy is the process by which cells break down and remove dysfunctional components, helping the body recycle proteins, eliminate waste, and destroy harmful cells. This cellular “self-cleaning” system was awarded the Nobel Prize in Physiology or Medicine in 2016, highlighting its importance in health and disease prevention.
During fasting, autophagy is significantly upregulated, allowing the body to focus on detoxifying and repairing itself rather than digesting food. Fasting Powder is designed to enhance this process by providing key nutrients that stimulate autophagy, optimize liver detoxification, and support overall cellular health.
Key Ingredients and Their Role in Autophagy:
Morus Alba (White Mulberry) Fruit Extract:
Morus alba is rich in antioxidants and flavonoids including morusinol, which are known to promote autophagy. These compounds help eliminate damaged cells, reduce oxidative stress, and protect against inflammation, allowing the body to focus on cellular repair and regeneration. Research suggests that morusinol may mimic some of the benefits of fasting by triggering autophagy-related pathways.
Morus alba leaves ethanol extract protects pancreatic islet cells against dysfunction and death by inducing autophagy in type 2 diabetes
DOI: https://doi.org/10.1016/j.phymed.2021.153478
Morusinol Extracted from Morus alba Inhibits Cell Proliferation and Induces Autophagy via FOXO3a Nuclear Accumulation-Mediated Cholesterol Biosynthesis Obstruction in Colorectal Cancer
DOI: https://pubs.acs.org/doi/10.1021/acs.jafc.3c01244.
Morusin induces apoptosis and autophagy via JNK, ERK and PI3K/Akt signaling in human lung carcinoma cells
DOI: https://doi.org/10.1016/j.cbi.2020.109279
Induction of cytoprotective autophagy by morusin via AMP-activated protein kinase activation in human non-small cell lung cancer cells
DOI: https://doi.org/10.4162/nrp.2020.14.5.478
Carica papaya extract:
Papaya contains a potent enzyme called papain, known for its digestive and anti-inflammatory properties. However, in the context of autophagy, papaya’s high content of vitamins, particularly vitamin C and antioxidants, plays a crucial role in cellular health. The detoxifying enzymes in papaya help break down proteins and cleanse cellular debris, which complements the autophagy process during fasting.
Unripe Carica papaya Protects Methylglyoxal-Invoked Endothelial Cell Inflammation and Apoptosis via the Suppression of Oxidative Stress and Akt/MAPK/NF-κB Signals
DOI: https://doi.org/10.3390/antiox10081158
Anticancer Activity of Phytochemicals of the Papaya Plant Assessed: A Narrative Review
DOI: https://doi.org/10.15430/JCP.24.020
Camellia sinensis (40% EGCG extract):
Green and black tea extracts are renowned for their polyphenols, particularly catechins like EGCG (Epigallocatechin gallate). These compounds have been found to enhance autophagy by activating key cellular pathways that help eliminate dysfunctional cells. EGCG supports the process of detoxification, especially in the liver, where it aids in clearing toxins and improving metabolic health. The antioxidants in tea also protect cells from damage and help manage the stress caused by fasting.
A Review of the Role of Green Tea (Camellia sinensis) in Antiphotoaging, Stress Resistance, Neuroprotection, and Autophagy
DOI: https://doi.org/10.3390/nu11020474
Saponins Extracted from Tea (Camellia Sinensis) Flowers Induces Autophagy in Ovarian Cancer Cells
DOI: https://doi.org/10.3390/molecules25225254
Green Tea Polyphenol Catechins Inhibit Coronavirus Replication and Potentiate the Adaptive Immunity and Autophagy-Dependent Protective Mechanism to Improve Acute Lung Injury in Mice
DOI: https://doi.org/10.3390/antiox10060928
Curcuma longa (Turmeric):
Curcumin longa, the active compound in turmeric, is a powerful anti-inflammatory and antioxidant that has been shown to stimulate autophagy. By reducing oxidative stress and inflammation, curcumin creates an optimal environment for autophagy to occur. It also supports liver detoxification, a key aspect of cellular cleansing, ensuring the efficient breakdown and elimination of toxins.
Curcumin activates autophagy and attenuates oxidative damage in EA.hy926 cells via the Akt/mTOR pathway
DOI: https://doi.org/10.3892/mmr.2016.4796
Turmeric Toxicity in A431 Epidermoid Cancer Cells Associates with Autophagy Degradation of Anti-apoptotic and Anti-autophagic p53 Mutant
DOI: https://doi.org/10.1002/ptr.5196
Curcumin-induced autophagy contributes to the decreased survival of oral cancer cells
DOI: https://doi.org/10.1016/j.archoralbio.2012.04.005
Zingiber officinale extract:
Zingiber officinale, ginger is known for its digestive benefits, but it also plays a significant role in stimulating autophagy. The active components in ginger, such as gingerol and shogaol, help reduce inflammation and support cellular health by encouraging the removal of damaged components. Ginger also aids in detoxification by supporting liver function and promoting the efficient breakdown of waste products.
Zingiber officinale promotes autophagy and apoptosis in human oral cancer through the C/EBP homologous protein
DOI: https://doi.org/10.1111/cas.16248
Zingiberene inhibits in vitro and in vivo human colon cancer cell growth via autophagy induction, suppression of PI3K/ AKT/mTOR Pathway and caspase 2 deactivation
DOI: article
8-Gingerol Ameliorates Myocardial Fibrosis by Attenuating Reactive Oxygen Species, Apoptosis, and Autophagy via the PI3K/Akt/mTOR Signaling Pathway
DOI: https://doi.org/10.3389/fphar.2021.711701
Malpighia emarginata extract:
Acerola, a tropical fruit extremely high in vitamin C, supports the immune system and acts as a potent antioxidant. Vitamin C is essential for the maintenance and repair of tissues, as well as for promoting autophagy. Acerola helps protect cells from oxidative stress and accelerates the detoxification process by supporting liver function and the elimination of free radicals.
Acerola (Malpighia emarginata) Anti-Inflammatory Activity—A Review
DOI: https://doi.org/10.3390/ijms25042089
Modulation of Autophagy in Cancer Cells by Dietary Polyphenols
DOI: https://doi.org/10.3390/antiox10010123
How Fasting Powder Enhances Autophagy and Detoxification?
- Autophagy Stimulation: The carefully selected ingredients in Fasting Powder work together to activate autophagy pathways. By promoting cellular recycling and eliminating damaged or dysfunctional cells, the body can focus on repair and rejuvenation, leading to better overall health.
- Liver Detoxification Support: Several ingredients in Fasting Powder, particularly curcumin, ginger, and tea extract, are known to enhance liver function. The liver is a key organ for detoxification, processing waste and toxins from the bloodstream. Supporting liver health allows for a more efficient detoxification process during fasting.
- Anti-inflammatory and Antioxidant Properties: Chronic inflammation and oxidative stress can interfere with autophagy and overall cellular function. Fasting Powder’s blend of turmeric, ginger, and tea extract reduces inflammation and protects cells from damage, ensuring the autophagy process runs smoothly.
- Appetite Suppression: Managing hunger is one of the biggest challenges of intermittent fasting. Fasting Powder helps curb cravings, making it easier to stick to a fasting schedule. The natural appetite-suppressing effects of ingredients like ginger and tea extract provide a more comfortable fasting experience.
How to Use Fasting Powder:
Mix ½ to 1 teaspoon of Fasting Powder into 200-300ml of water and drink on an empty stomach. For best results, take it around 9-10 a.m., especially if practicing intermittent fasting. Wait until 12 p.m. to eat, allowing your body to benefit from enhanced autophagy and detoxification during your fasting window.
Fasting Powder is more than just a supplement; it’s a scientifically formulated tool designed to help you harness the incredible benefits of autophagy, making your intermittent fasting more effective. By combining powerful natural herbs with cutting-edge research, Fasting Powder supports cellular health, detoxification, and hunger control—all while helping your body naturally eliminate damaged cells and toxins.
The process of Autophagy in the cell
